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KMID : 0606920130210040284
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Biomolecules & Therapeutics
2013 Volume.21 No. 4 p.284 ~ p.289
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Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
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Hong Su-Hee
Heo Jee-In
Kim Jeong-Hyeon
Kwon Sang-Oh
Yeo Kyung-Mok
Bakowska Barczak Anna M.
Kolodziejczyk Paul
Ryu Ok-Hyun
Choi Moon-Ki
Kang Young-Hee
Lim Soon-Sung
Suh Hong-Won
Huh Sung-Oh
Lee Jae-Yong
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Abstract
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Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
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KEYWORD
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Antidiabetes, Purple corn anthocyanins, Beta cell-protection, Antihyperglycemic activity, Pancreatic beta cell, db/db Mice
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